The former Stephen H Smith garden centre site in Scunthorpe is to be transformed into a £25m retail park featuring a Marks & Spencer and Debenhams, with work beginning next month.
Simons Developments plans to start building steel frames for the shop units from mid-February.
The M&S development is also set to include Boots, Subway and Costa Coffee outlets and will create around 300 jobs.
The new stores are expected to open this autumn.
Works started at the end of November with the demolition of the old garden centre.
Nearly 1,500 ornamental carp and some 20 birds residing in the existing pond to the rear of the garden centre were transported to a new lake to the south of the area, while most of the birds have been relocated to one of Stephen H Smith's other garden centres.
Planning permission was granted by North Lincolnshire Council in December 2011 and again in March 2012. The decision by the council's planning committee was then upheld by a High Court judge following a judicial review.