New Hall Vineyards of Essex took the Waitrose Trophy for most outstanding still rose and won the English Wine Producers Dudley Quirk Memorial Trophy for best large production.
Chapel Down, the sole winner from the South East, took three awards - the Wine Guild Trophy for its Bacchus Reserve 2011, the McNie Trophy for most outstanding oaked white wine and the Bernard Theobald Trophy for best red.
A total 11 gold, 68 silver and 69 bronze medals were awarded. Some 189 wines were judged over two days by a team of six masters of wine, marking them to international standards.
UK Vineyards Association chairman Paul Langham said: "There are consistent winners each year, which shows just what good producers they are, and this year they are joined by the first wines of some of our newer names. The competition has not only illustrated the ongoing success of our country's sparkling wines but also the fantastic range of still white, rose and red wines."