The show will take place in the Matford Centre in Exeter in October and has sold more than 60 stands so far.
Show chairman Mark Taylor said: "We have always stressed that the South West Growers Show is a show run by growers, for growers. It is therefore testimony to its success that we can now report a healthy increase in growers exhibiting this year.
"Firmly established as one of the leading UK commercial horticultural exhibitions, it continues to go from strength to strength."
Plant cash and carry Jackson & Son is among the growers attending and is researching a number of new introductions to launch at the show. Managing director David Jackson said: "We sell annual plug plants to trade and amenity in the South West, often tailored to the smaller, independent customer, and so the show's timing is perfect for our customer base."
Devon-based wholesale supplier Rainbow Plants will also return. Owner Bob Joy said: "The show is an important event for us. It provides us with an opportunity to showcase new varieties, meet other growers as well as existing and potential customers all under one roof."