The petition to the Prime Minister urges the Government to keep land-based vocational subjects studied by teenagers in the 2015 school league tables.
So far 2,063 people have signed.
The school fears that when these are taken out his school, where all pupils study two land-based BTECs, will appear to be doing badly, when it has previously scored highly. In 2011-12 it was in the top 3% of schools which made progress compared to target grades.
However the Government believes changes need to be made to make vocational courses more rigorous.
Head teacher Mark Thomas said: "It's fantastic if I'm honest. When we started it we didn't expect it to hit the nerve that it's had with so many people. We've got so many people invovled doing something about it."
Students, their parents and former students have all been lobbying MPs and the school has had letters back from Secretary of State for Education, Michael Gove and the schools minister and Yeovil MP David Laws acknowleging they were aware of the issue.
Thomas told Horticulture Week earlier this month that he believed it was too late now to change the government’s mind in time for the 2015 tables, but he wanted to campaign for courses to be re-written quickly, so they could be reinstated as soon as possible.
Horticulture Matters, a report published last week by the RHS in association with 14 industry bodies, outlines a crisis in horticulture image and a widening skills gap.
The report found that 72% of horticulture businesses could not fill skilled vacancies, 90% think the career lacks appeal generally, 67% say career entrants are inadequately prepared for work and 19% are forced to recruit overseas.
It calls on the government to take action in seven different areas, including for the subject to be embedded in the curriculum from Key stage 1 to 4.
To sign the petition visit: http://www.change.org/en-GB/organisations/brymore_school.