The project for Wood Wharf is being bigged up as one of central London’s most exciting future waterfront developments.
PWP Landscape Architecture will create waterside parks meshed with European style-streets and squares.
The US-based practice has made a name for high-profile modern landscapes such as the National 9/11 Memorial in New York and the Sony Centre Plaza in Berlin.
Wood Wharf falls within a masterplan drawn up by architects at Terry Farrell and Partners.
Principal Peter Walker said the project was "complex and a challenge".
A planning application for the offices, homes and shops is due in spring and building could take 12 years. Parts could be open in time for Crossrail trains running through Canary Wharf from 2018.