Professor Alistair Hetherington said: "Unfortunately, this year we had only one applicant and when you are down to that level it questions the viability of running the course, so sadly we will no longer be offering botany as a degree subject.
"However, students on the biology course will have a thorough training in plant science. There is a benefit to understanding plant pathologies at molecular level."
Bristol's course is believed to be the last undergraduate degree course to contain the word "botany" in its title. However, an estimated 10 UK universities continue to offer plant science courses.