The initiative at Rumney Hill Gardens is a joint effort between the Daily Hope Foundation and Cardiff Council and will take place on 1 December.
The Cardiff Daffodil was developed to celebrate the 2005 centenary of Cardiff as a city and golden anniversary as the capital of Wales.
Many thousands of bulbs, described as have been planted in the city since then, grown and supplied by the Really Welsh Company.
Cabinet member for sport, leisure and culture Huw Thomas, said: "This is an important way of recognising the importance of World Aids Day and to consider those in the local communities who are living with illnesses related to HIV and AIDS."
Daily Hope Foundation runs the Campaign Trees For Life, a planting scheme to acknowledge those living with HIV and AIDS in the world and those who have died.