Site owner Keygrowing has another operator lined up, thought to be Klondyke, but needs planning approval to let the new chain sell its range of products.
Keygrowing managing director Jon Los said: "If we get the planning permission on Thursday, leases are already being drawn up."
Workers could be taken on by the new operator.
A single objector has raised concerns over what could be sold at the centre, meaning the application had to go to committee.
Thursday's application, which includes a list of items which can be sold, is recommended for approval.
In his report to councillors, East Riding of Yorkshire Council director of planning and regeneration Alan Menzies accepted the need for flexibility to secure jobs.
"Officers accept that modern, purpose-built garden centres have evolved from the more traditional garden centre model which sell principally 'green' products grown at or close to the site," he said.