In a letter sent to members of the RASE this week, chairman of trustees, Hugh Oliver-Bellasis, said the decision had been "a real challenge" but response to the show in recent years had left the society with little option.
"In the aftermath of the foot and mouth disaster in 2001 closely followed by very bad weather two years ago and blue tongue last year, the event has struggled both financially and in its ability to attract both farming and non-farming visitors.
This year's event will be the 160th Royal Show and the 46th to be held at Stoneleigh Park.
"We hope everyone will support the society and make a real effort to come to Stoneleigh between July 7th to 10th, have a great day out, enjoy the livestock, horses, technical features and shopping and bid a fond farewell to an event that has long been held in great affection by farmers and others who work and live in the British countryside," said Oliver-Bellasis.
RASE will create a new programme of events from 2010 onwards, the organisation said.
More on this year's Royal Show: www.royalshow.org.uk