Oudolf , known for the ‘New Perennial’ or ‘New Wave Planting’ styles, is working with horticulturist and writer Dr Noel Kingsbury on the project, which will teach people worldwide through MyGardenSchool.
The Planting the Piet Oudolf Way course starts on 14 October and costs £250 for four weeks. Students learn through video lessons shot at the Oudolf family garden at Hummelo in The Netherlands.
He said: "I know that many people across the world who I can’t reach would like to understand more about my planting philosophy and have personal recommendations.
"I maintain that structure is the most important component in a successful planting; colour is important too but it is a secondary consideration. To work with Noel and MyGardenSchool I hope means that we can share our planting philosophy."
Kingsbury, who has been teaching through the site for a number of years, called the venture "an exciting concept" which included a feature to give feedback in a virtual classroom.
MyGardenSchool founder Elspeth Briscoe said her product "solved an important problem for globally disparate enthusiasts in fragmented industries like horticulture and landscape design".
She said the website attracted a thriving community with experts such as Michael Marriott from David Austin Roses and industry veteren Andy McIndoe answering questions on roses and shrubs.
Students range from complete beginners through to horticulture professionals and come from 55 different countries.
Briscoe holds a post graduate diploma from the Oxford College of Garden Design.