The four-day show aims to be a "celebration of the UK's blooming and harvest season", and will be aimed at a relatively young audience and families, with early tickets selling for just £10. It will run from 8-11 September in the West London grounds of Osterley House and Park, owned by the National Trust.
Organisers are promising more than 20 show gardens, along with floral displays, produce-growing competitions, live entertainment, food, cooking shows and a children's area as well as the opportunity to wander the Osterley grounds.
Philippa O'Brien, chair of the Society of Garden Designers, said the new show looked like it would be "a breath of fresh air".
"Nothing stuffy about this one, it is aimed at a much younger audience than most shows, with plenty for families from growing vegetables to sustainable gardening. Show gardens look set to surprise and delight with lots of gardens designed by SGD members."
Horticulturist Nigel Gibson is the creative director behind the event. A number of other designers are in talks with organisers and are hoped to be revealed soon.
The inaugural London Flower Show was originally to launch in September 2015 at Victoria Park but was cancelled last July. A show spokesperson said there were "logistical difficulties" with the original venue around show garden builds, so the organisers decided to relocate "for the benefit of the event and visitor experience".
The new venue of Osterley is a Georgian country estate features formal gardens which were transformed over six years from an overgrown wilderness back to their original 18th-century grandeur, with herbaceous borders, roses and ornamental vegetables beds, a summerhouse filled with lemon trees and scented shrubs, a woodland, lake and ancient meadow.