The council is planning 590,000m2 of commercial development and forecasts that the regeneration will create 37,000 new jobs by 2043.
Councillor Rachel Bailey, leader of Cheshire East Council, said: "The Crewe masterplan gives an insight into the future of the town. The council is both a major investor and a major advocate for Cheshire East and it is right that the local authority commits time and resources to build market confidence and promote Cheshire East as a great place to be – and help deliver jobs, investment and greater opportunities for all our residents.
"With HS2 coming to Crewe in 2027, the town is set to become one of the most connected places in the UK and a great place to invest and do business. This will be a revolutionary change for the area as Crewe will be only 25 minutes by train from central Manchester and Birmingham as well as being less than an hour from central London."