Homeware and garden chain The Range plans to open 45 new stores in the next three years.
Owner Chris Dawson said the move would create more than 5,000 jobs in England and Wales and 1,750 jobs in Scotland. The company has 76 stores across the UK employing more than 7,000 people
Later this year, Dawson plans to open stores in Dudley, Edinburgh, Milton Keynes, Southend-on-Sea and Dundee. He aims to open 20 further stores across the UK in 2014.
Last week Dawson opened his first branch in Scotland, in Glasgow.
He plans expansion into Europe.
The business began in Plymouth in 1989.