Glendale's new contract to deliver grounds maintenance for social housing provider Newport City Homes in South Wales lasts four years.
The ground floor space has been fitted out as industrial space with integral office and ancillary accommodation set over two floors.
Terry Doyle, regional director for Glendale in the South West and South Wales, said: "Glendale is pleased to take over the lease of the unit at Maesglas Industrial Estate.
"The unit is perfectly suited to deliver our grounds and tree maintenance services for our clients in Newport and it is in an excellent location for our planned expansion into South Wales."
Harriet Costello, of JLL in Cardiff, which also manages the estate, said: "The fact that Maesglas Industrial Estate is close to full occupancy is positive news for Newport’s industrial trade counter market. It also shows that demand for trade counter space remains high against a backdrop of short supply."