Dan Zinner leaves after two years running trading, while Tim Patten goes after two years setting up Wyevale's multichannel offer, which is yet to launch.
Homebase commercial director Paul Emslie is new trading and marketing director, while Richard Morgan, formerly of Euro Car Parts, Home Retail Group, Coca Cola and Cadbury is new supply chain director.
The multi channel offer, is due to launch shortly and the transactional site is being built.
Patten is joining TM Lewin while Zinner's new role is unknown.
There are no developments on Wyevale's pursuit of Dobbies, though former and current Dobbies chiefs James Barnes and Andy King are rumoured to be interested, backed by private equity funds.
The sale by Tesco of Dobbies is expected to go through at the end of May.