West Sussex-grown Nyetimber Classic Cuvee 2003 was crowned "champion of worldwide sparkling wines" taking the highest marks and the gold medal in the competition, named Bollicine del Mondo.
Cornwall's Camel Valley's Pinot Noir Brut 2007 featured in the top ten, winning the competition's award for "best rest of the world".
These two English wines came ahead of champagnes Canard Duchene and Louis Roederer Millesime 2000, which featured in the top ten.
Nyetimber Blanc de Blancs 2001 was also in the top 12 wines in the competition, out of a total of 52 entries.
Now in its second year, Bollicine del Mondo attracts sparkling wines from all over the world. The competition is only open to traditional method, traditional varietal wines. Camel Valley won a silver medal in last year's competition, behind Bollinger Champagne.
The wines were tasted blind by a panel of oenologists, wine-makers, sommeliers and journalists led by Ais Veneto president Dino Marchi.
Euposia director Beppe Giuliano said: "This is an outstanding success for England and my congratulations go to Nyetimber for its win and to Camel Valley for another excellent result.
"We were so impressed with the variety of wine regions that were represented in this competition and the increased number of entries."