The group said the proposed Heathrow north western runway would destroy 694ha of green belt and 60ha of woodland and ruin the tranquility of many parks and gardens, including impacting on the Chilterns Area of Outstanding Natural Beauty.
CPRE transport campaign manager Ralph Smyth said: "Besides the destruction of much of the ancient village of Harmondsworth to make way for the new runway, a much wider area is at threat. On top of the almost relentless din of jet engines, runaway development and traffic would shatter the remaining fragments of tranquil countryside in the south east, already one of the most densely overflown areas in the world."
Smyth added that all of the shortlisted options would have a "devastating impact" on the countryside. CPRE is instead in favour of rebalancing growth and using the spare capacity of airports in other UK cities.