Homebase managing director PJ Davis said: "It has always been our intention to stay within the Milton Keynes area and it will be great to have our own offices and continue to work towards building strong foundations for our business."
The office is currently shared with Argos, which is now owned by Sainsbury's since the break up of Home Retail Group this year and the sale of Homebase to Wesfarmers for £340m.
Wesfarmers will rename Homebase as Bunnings next year and four-to-six pilot Bunnings Warehouse stores situated "north of London" will open between February 2017 - at the start of the gardening season - and the end of the financial year on 30 June 2017.
Wesfarmers added in its release of results for the first quarter of its financial year: "There is a strong focus within the business on continuing to transition core ranges across to home improvement and garden products. Pleasing progress is being made with this work."
Home improvement division chief executive officer John Gillam said the implementation of new pricing, marketing and operational strategies within Homebase is achieving results "in line with plans".