The discount retailer has more than 500 stores across the UK selling a variety of products, from food and drink to toys, homewares and a DIY range.
Last year B&M said it sold enough artificial turf to cover more than nine football pitches, enough fence panels to cross the channel five times and more than five million plants.
The retailer opened their first garden centre in 2011 as part of their Leek store on Barnfields Road and have rapidly increased their portfolio to 100 in just five years.
The new Salisbury store, the 100th B&M garden centre, located on the Southampton Road Retail Park, has created more than 80 jobs for local people in a welcome boost to the local economy.
Chief operating executive Simon Arora said: "We are delighted to reach this milestone at our Garden Centre division, which now has the critical mass to be an important player in the sector."